Biology of Treponema pallidum

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Shape of Treponema pallidum.

Treponema pallidum was found to be not helical, but a flat wave twisted into one to five different planes per cell.

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Mucopolysaccharidase of Treponema pallidum.

Treponema pallidum (Nichols strain) exhibited mucopolysaccharidase activity. Acidic mucopolysaccharides were broken down more rapidly by viable treponemes than by heat-inactivated treponemes or membrane filtrates of treponemal suspensions. Ouchterlony immunodiffusion demonstrated the occurrence of antibodies to the hyaluronidase-like enzyme within syphilitic sera. After intratesticular inoculat...

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Ionic Requirements of Treponema Pallidum

DOAK, G. 0. (University of North Carolina, Chapel Hill), LEON D. FREEDMAN, AND JOHN W. CLARK, JR. Ionic requirements of Treponema pallidum. III. Divalent ions. J. Bacteriol. 82:909912. 1961.-Suspensions of Treponema pallidum, prepared by extracting the testes of syphilitic rabbits with normal rabbit serum or with a culture medium, were shaken with Amberlite IRC-50 resin in the sodium ion form. ...

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Treponema pallidum in nerve fibres.

Ultrathin sections of a rabbit scrotal syphiloma were examined by electron microscopy. Treponemes were observed in the endo-, peri-, and epineurium of the nerve fibre. The significance of these findings, in that infection may be transmitted via the nerve fibres and pain reduced by damage to the afferent fibres, are discussed.

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Oxygen uptake by Treponema pallidum.

Virulent Treponema pallidum has been shown to consume O(2) at a rate similar to that of the known aerobic spirochaete, Leptospira. Such O(2) uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O(2) uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduce...

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ژورنال

عنوان ژورنال: Sexually Transmitted Infections

سال: 1970

ISSN: 1368-4973

DOI: 10.1136/sti.46.4.338